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KMID : 0882420150890050558
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Korean Journal of Medicine
2015 Volume.89 No. 5 p.558 ~ p.562
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Sick Sinus Syndrome Following Severe Hyponatremia Associated with Desmopressin Therapy
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Sohn Young-Seok
Kang Min-Ku
Kim Young-Il
Lee Jun-Han
Park Jin-Kyu
Kim Soon-Gil
Shin Jeong-Hun
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Abstract
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Desmopressin diacetate arginine vasopressin (DDAVP) is a synthetic analogue of the arginine vasopressin that is widely used in the treatment of diabetes insipidus, nocturnal enuresis, and polyuria. Although it is generally well-tolerated, DDAVP can cause hyponatremia, especially in elderly patients. There are many reports of DDAVP-induced hyponatremia, but there has been only one case report in which sinus node dysfunction was caused by severe hyponatremia. Here we report a case of sick sinus syndrome that occurred during an episode of severe hyponatremia induced by chronic use of desmopressin in a 91-year-old man who had nocturnal enuresis.
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KEYWORD
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Deamino arginine vasopressin, Hyponatremia, Sick sinus syndrome
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